The effects of estradiol on cardiac muscle electrophysiology in orchiectomized rat model: a new insight to side effects caused by castration

Ayaz M., Akand M., Kucukbagriacik Y., Dursunoglu D.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.19, sa.15, ss.2866-2874, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 15
  • Basım Tarihi: 2015
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2866-2874
  • Anahtar Kelimeler: Electrophysiology, Orchiectomy, Rat, 17 beta estradiol, Androgen depletion, GENDER-DIFFERENCES, 17-BETA-ESTRADIOL, HEART, TESTOSTERONE, REPLACEMENT, WOMEN, RISK, MEN
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

OBJCTIVE: Although the testosterone has a protective effect on heart, patients having maximal androgen blockade due to prostate cancer resembles endothelial dysfunction and cardiac problems when compared to normal population. We aimed to test the effect of 17 beta estradiol on the orchiectomized male rat heart electrophysiology and ion channel expression levels.