The effects of estradiol on cardiac muscle electrophysiology in orchiectomized rat model: a new insight to side effects caused by castration


Ayaz M., Akand M., Kucukbagriacik Y. , Dursunoglu D.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.19, no.15, pp.2866-2874, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 15
  • Publication Date: 2015
  • Title of Journal : EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Page Numbers: pp.2866-2874
  • Keywords: Electrophysiology, Orchiectomy, Rat, 17 beta estradiol, Androgen depletion, GENDER-DIFFERENCES, 17-BETA-ESTRADIOL, HEART, TESTOSTERONE, REPLACEMENT, WOMEN, RISK, MEN

Abstract

OBJCTIVE: Although the testosterone has a protective effect on heart, patients having maximal androgen blockade due to prostate cancer resembles endothelial dysfunction and cardiac problems when compared to normal population. We aimed to test the effect of 17 beta estradiol on the orchiectomized male rat heart electrophysiology and ion channel expression levels.