Serum sirtuin 1 levels in patients with polycystic ovary syndrome

Caglayan E. K. , Engin-Ustun Y., GÖÇMEN A. Y. , POLAT M. F. , Aktulay A.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.35, no.6, pp.608-611, 2015 (SCI-Expanded) identifier identifier identifier


Objective of the study is to determine the human nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 level in women with polycystic ovary syndrome (PCOS). This cross-sectional study included 24 patients aged 20-38 years, who were diagnosed to have PCOS (patient group). The control group included 16 age-and body mass index-matched healthy female volunteers. The patients and controls were compared in terms of pre-prandial blood glucose, the homoeostatic model assessment for insulin resistance (HOMA-IR) index, and cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP) and sirtuin 1 levels.