Serum sirtuin 1 levels in patients with polycystic ovary syndrome

Caglayan E. K., Engin-Ustun Y., GÖÇMEN A. Y., POLAT M. F., Aktulay A.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.35, no.6, pp.608-611, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.3109/01443615.2014.990428
  • Journal Name: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.608-611
  • Keywords: PCOS, sirtuin 1, INSULIN-RESISTANCE, HISTONE DEACETYLASES, INFLAMMATION, GLUCOSE, HOMEOSTASIS, PHYSIOLOGY, DISORDERS, PROTECTS, DISEASE, ROLES
  • Yozgat Bozok University Affiliated: Yes

Abstract

Objective of the study is to determine the human nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 level in women with polycystic ovary syndrome (PCOS). This cross-sectional study included 24 patients aged 20-38 years, who were diagnosed to have PCOS (patient group). The control group included 16 age-and body mass index-matched healthy female volunteers. The patients and controls were compared in terms of pre-prandial blood glucose, the homoeostatic model assessment for insulin resistance (HOMA-IR) index, and cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP) and sirtuin 1 levels.