The Effects on Antioxidant Enzyme Systems in Rat Brain Tissues of Lead Nitrate and Mercury Chloride


BAŞ H. , KALENDER S., KARABODUK H., APAYDIN F. G.

GAZI UNIVERSITY JOURNAL OF SCIENCE, vol.28, no.2, pp.169-174, 2015 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2015
  • Title of Journal : GAZI UNIVERSITY JOURNAL OF SCIENCE
  • Page Numbers: pp.169-174

Abstract

The present study was undertaken to evaluate the effects of lead nitrate and mercury chloride in brain tissues of Wistar rats. Mercury chloride (0.02 mg/kg bw) and lead nitrate (45 mg/kg bw) were administered orally for 28 days rats. The mercury chloride and lead nitrate treated animals were exhibited a significant inhibition of superoxide dismutase, catalase, glutation peroxidase and glutathione-S-transferase activities and increasing of malondialdehyde levels. In our present study mercury chloride caused more harmful effects than lead nitrate. The effect which we observed applying the lead nitrate and mercury chloride together, was more greater than when we used them alone.