Akademik Veri Yönetim Sistemi
Joint Bone Spine, cilt.73, sa.3, ss.334-336, 2006 (SCI-Expanded, Scopus)
Familial Mediterranean fever (FMF) is an autosomal recessive disorder of unknown etiology. Although our understanding of the pathogenesis and genetics of FMF has greatly enhanced after the discovery of the MEFV/marenostrin gene, genetic susceptibility to FMF can not be solely attributed to the mutations in MEFV/marenostrin gene [1]. Hence, identification of other susceptibility loci is currently awaited. FMF is characterized by recurrent serosal, synovial and/or cutaneous inflammation. Moreover, those patients have subclinical inflammation in the attack-free periods [2]. Recent advances demonstrated that angiotensin II is an important component of the inflammatory response [3]. Angiotensin converting enzyme (ACE) hydrolyses inactive angiotensin I into active angiotensin II. Thus ACE plays a regulatory role in the renin-angiotensin system (RAS). A polymorphism of the ACE gene has recently been described that affects circulating and tissue levels of the ACE [4,5]. In this study, we aimed to investigate the frequency of the different alleles of the ACE gene in a cohort of Turkish patients with FMF in an attempt to identify genetic susceptibility loci for FMF other than MEFV/marenostrin gene. © 2006 Elsevier SAS. All rights reserved.