EVALUATION OF THE EFFECT OF CANNABIDIOL ON MDA-MB-231 TYPE BREAST CANCER CELL
PONTE, vol.79, no.9/1, pp.1-12, 2023 (AHCI)
- Publication Type: Article / Article
- Volume: 79 Issue: 9/1
- Publication Date: 2023
- Doi Number: 10.21506/j.ponte.2023.9.8
- Journal Name: PONTE
- Journal Indexes: Arts and Humanities Citation Index (AHCI), Periodicals Index Online, American History and Life, Historical Abstracts, MLA - Modern Language Association Database
- Page Numbers: pp.1-12
- Yozgat Bozok University Affiliated: No
Abstract
The aim of this study was to investigate the effect of CBD injection on breast cancer MDAMB-
231 type cells on cell proliferation and cell survival.
MDA-MB-231 cells were obtained from the Public University Genome and Stem Cell
Institute. CBD was obtained from Yozgat Bozok University Hemp Research Institute. CBD
was dissolved in dimethyl sulfoxide (DMSO). Cell cultures were injected with CBD
concentrations of 5, 10, 25, 50 and 100 μM. The toxic effect of DMSO on cells in which it
was injected in pure form was found to be limited. CBD slowed down the division and
proliferation by acting on MDA-MB-231 type cells. The most effective dose was determined
to be 10 μM CBD concentration. As a result, CBD slowed down the cell cycle by acting on
MDA-MB-231 type cells. According to this study, it can be recommended to investigate CBD
concentrations between 6-24 μM in animal experiments.