Aim To evaluate the effects of a nurse-led intervention programme on compassion fatigue, compassion satisfaction, and burnout, which are indicators of the professional quality of life and post-traumatic growth of oncology nurses. Method The study was designed in a single group with pre-test and post-test comparisons. The nurse-led intervention programme was carried out in two face-to-face sessions and two counselling follow-up sessions by phone with 43 nurses who care for oncology patients at a university hospital. The nurse-led intervention sessions consisted of a lecture on a relevant topic, background reading, baksi dance and mandala painting; motivational text messages and counselling. The Professional Quality of Life-IV Scale and the Post-Traumatic Growth Inventory were used, and data were evaluated using the "paired groups t test" analysis. Data for the study were acquired between March and April 2016. Results The evaluation carried out before and 5 weeks after the intervention showed that compassion fatigue and burnout decreased, while compassion satisfaction and all subscales scores of post-traumatic growth inventory increased. Conclusion This nurse-led intervention programme was effective in improving the professional quality of life and post-traumatic growth of oncology nurses.