Objective: To demonstrate the feasibility of retrograde intrarenal surgery (RIRS) in the treatment of 2-3 cm multicalyceal kidney stones considering the possible complications and unsuitable situations. Multiple kidney stones are observed among 20-25% of patients seen in urology clinics. Percutaneous nephrolithotomy (PNL) is the primary method for treating kidney stones larger than 2 cm. Despite the high success rate achieved, life-threatening complications associated with PNL may arise. Multiple accesses may be required for multiple stones. RIRS has become increasingly widely used. In our study, we aimed to compare these two methods in the treatment of 2-3 cm multicalyceal stones.