COMPARISON OF THE EFFECTS OF AUTOLOGOUS CYTOKINE-RICH SERUM (ACRS) AND PLATELET-RICH PLASMA (PRP) ON SKIN WOUND HEALING

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Erol H., Karakaş E., Ermiş M., Akçakavak G., Aslan N. E., Karataş Ö.

ACTA VETERINARIA, vol.75, no.2, pp.151-165, 2025 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 75 Issue: 2
  • Publication Date: 2025
  • Doi Number: 10.2478/acve-2025-0013
  • Journal Name: ACTA VETERINARIA
  • Journal Indexes: Food Science & Technology Abstracts, Scopus, Science Citation Index Expanded (SCI-EXPANDED), Academic Search Premier, BIOSIS, Central & Eastern European Academic Source (CEEAS), EMBASE, CAB Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.151-165
  • Open Archive Collection: AVESIS Open Access Collection
  • Yozgat Bozok University Affiliated: Yes

Abstract

Wound healing is one of the most complex biological events, involving physiological processes such as tissue restoration and intricate cellular and molecular activities. The aim of this study was to investigate the effects of Autologous Cytokine Rich Serum (ACRS) and Platelet-rich plasma (PRP) on wound healing and to compare their impact on tissue repair using histopathological and immunohistochemical methods. A total of 42 healthy Wistar-Albino rats were used as material. The histopathological and immunohistochemical evaluations showed that ACRS is more effective than PRP on wound healing. The superior efficacy of ACRS is attributed to its stimulation of anti-inflammatory cytokines and provision of essential nutrients such as amino acids, vitamins, and lipids. Further detailed studies are recommended to explore these findings.