Association of elevated plasma homocysteine levels with impaired ST-segment resolution after fibrinolytic therapy in acute ST-elevation myocardial infarction
Coronary Artery Disease, cilt.19, sa.3, ss.163-166, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 3
- Basım Tarihi: 2008
- Doi Numarası: 10.1097/mca.0b013e3282f5292d
- Dergi Adı: Coronary Artery Disease
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.163-166
- Anahtar Kelimeler: Homocysteine, Myocardial infarction, ST-segment resolution
- Yozgat Bozok Üniversitesi Adresli: Evet
Özet
OBJECTIVE: Elevated plasma homocysteine levels are associated with increased intracoronary thrombus burden in acute coronary syndromes. The relationship between plasma homocysteine levels and ST-segment resolution (STR) after fibrinolytic therapy has, however, not been investigated. We sought to investigate this issue. METHODS: Forty-nine patients who were administered fibrinolytic therapy for ST-segment elevation myocardial infarction (STEMI) were included in this study. Maximum STR was measured after 90 min of fibrinolytic therapy. Patients with a maximum STR of less than 50% were included in group 1. Patients with a maximum STR ≥50% were included in group 2. Blood samples were collected from the antecubital vein upon arrival to the hospital. The plasma was separated and kept at -70°C until the time of analysis. Total plasma homocysteine level was determined by the high-performance liquid chromatography method with fluorescence detection. RESULTS: Fifteen patients in group 1 and 34 patients in group 2 were present. Baseline characteristics were similar in both groups. The plasma homocysteine levels were 22.5±10 μmol/l in group 1 and 14.1±4 μmol/l in group 2 (P<0.001). CONCLUSION: Elevated plasma homocysteine levels are associated with impaired STR after fibrinolytic therapy in acute STEMI. © 2008 Lippincott Williams & Wilkins, Inc.