Assessment of Endothelial Dysfunction with Methylated Arginines and L-arginine in Cadmium-Exposed People: a Pilot Study


Tutkun L., Gunduzoz M., TÜRKSOY V. A. , Deniz S., Oztan O., Cetintepe S. P. , ...More

CLINICAL LABORATORY, vol.65, no.10, pp.1821-1828, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 10
  • Publication Date: 2019
  • Doi Number: 10.7754/clin.lab.2019.181249
  • Title of Journal : CLINICAL LABORATORY
  • Page Numbers: pp.1821-1828
  • Keywords: cadmium exposure, atherosclerosis, asymmetric dimethyl arginine (ADMA), endothelial dysfunction, methylated arginines, ASYMMETRIC DIMETHYLARGININE ADMA, RISK-FACTOR, ATHEROSCLEROSIS, MECHANISMS, ZINC, METABOLISM, RATIO, LEAD

Abstract

Background: Workers can be exposed to cadmium (Cd) in various industries. On the other hand, another potential source for Cd exposure is the food chain and smoking. Environmental pollution to Cd plays an important role in the development of atherosclerosis. Asymmetric dimethyl arginine (ADMA) levels promote the development of endothelial dysfunction and atherosclerosis-related diseases such as hypertension, acute coronary syndrome, congestive heart failure, and peripheral vascular diseases. The aim of this study is to evaluate the cardiovascular risks of non-symptomatic cadmium-exposed workers and to promote the value of methylated arginines in screening of toxic exposures.