In this work, a new design for a real-time noninvasive metamaterial sensor, based on a corona-shaped resonator, is proposed. The sensor was designed numerically and fabricated experimentally in order to be utilized for efficient detection of glucose in aqueous solutions such as water and blood. The sensor was inspired by a corona in-plane-shaped design with the presumption that its circular structure might produce a broader interaction of the electromagnetic waves with the glucose samples. A clear shift in the resonance frequency was observed for various glucose samples, which implies that the proposed sensor has a good sensitivity and can be easily utilized to distinguish any glucose concentration, even though their dielectric coefficients are close. Results showed a superior performance in terms of resonance frequency shift (1.51 GHz) and quality factor (246) compared to those reported in the literature. The transmission variation level increment |S21| was investigated for glucose concentration in both water and blood. The sensing mechanism was elaborated through the surface current, electric field and magnetic field distributions on the corona resonator. The proposed metamaterials sensor is considered to be a promising candidate for biosensor and medicine applications in human glycaemia monitoring.